My observation here is that the noise reduction/sharpen details work that has been done on this detracts from the final image. I know it's difficult when you need to crop, however if you know this when taking the shot then it's worth seeing what you can do to limit the noise you will get...knowing that it will be exaggerated when you crop in.
I noticed that your shutter speed looked a bit high and it made me think that you may get away with a slower speed - say 250 or 125 maybe. And also the aperture may possibly have been a bit larger - say 5.6. All this would allow to reduce the iso to a maximum of 1000 (potentially lower) and therefore reduce the amount of noise to remove. Obviously I don't know what the light was like for you but I know you've talked in the forums about noise so thought this might be a useful observation.
There's another shot that was uploaded recently
that shows these sorts of settings and what can be achieved. I'm not saying the other shot is perfect, and it looks like they may have been much closer than you were to your subject but the exif info may be useful for you.