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Printing for first time

I have an image 2547x3275 pixels and want to resize it to print at 16” x 12”. At the moment I am doing image resize in CS2 and not getting the size 16 x 12 its coming out 16 x 12.443
The dpi is 300, when resizing up to 16 x 12 will I lose quality on the final print? I have never printed anything at this sort of size.
The dpi is 300, when resizing up to 16 x 12 will I lose quality on the final print? I have never printed anything at this sort of size.

using your crop tool type in 16" x 12" at 200ppi, then look at the detail at print size, 200ppi gives you the file size at 16x20, you need to view the image from a few feet away because you don't normally look at an A2 close up
I got pointed to here some good reading regarding print size and ppi
I got pointed to here some good reading regarding print size and ppi